Modifying Woodward–Hoffmann Stereoselectivity Under Vibrational Strong Coupling

Vibrational strong coupling (VSC) has recently been shown to change the rate and chemoselectivity of ground-state chemical reactions via formation light–matter hybrid polaritonic states. However, observation that vibrational-mode symmetry a large influence on charge-transfer under VSC suggests considerations could be used control other types selectivity through VSC. Here, we show influences stereoselectivity thermal electrocyclic ring opening cyclobutene derivative, reaction which follows Woodward–Hoffmann rules. The direction in depends vibrational mode is coupled, as do changes thermodynamics. These results pericyclic confirm plays key role chemistry