Modifying Histones and Initiating Meiotic Recombination
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چکیده
منابع مشابه
Modifying Histones and Initiating Meiotic Recombination New Answers to an Old Question
It is well documented that the formation of the DNA double-strand breaks (DSBs) that initiate meiotic recombination is influenced by chromatin and larger scale chromosome organization, but the molecular nature of this influence has remained elusive. Several recent studies, including (this issue of Cell), shed light on this issue by revealing roles for posttranslational histone modifications in ...
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Meiotic recombination is essential for the production of viable haploid gametes in sexually-reproducing organisms, and creates new allelic combinations, whichmay facilitate evolution by natural selection and genetic drift (Barton & Charlesworth, 1998). Crossovers between homologous chromosomes establish physical connections (chiasmata) which enable proper chromosome segregation. In the absence ...
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Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies. It should be possible to identify these abnormal crossover configurat...
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Many studies have demonstrated that the distribution of meiotic crossover events along chromosomes is non-random in plants and other species with sexual reproduction. Large differences in recombination frequencies appear at several scales. On a large scale, regions of high and low rates of crossover have been found to alternate along the chromosomes in all plant species studied. High crossover ...
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Meiotic recombination generates gene conversion and crossover events that are distributed heterogeneously in the genome. Studies in yeast show that initiation of recombination, which occurs by the formation of DNA double-strand breaks, determines the distribution of gene conversion and crossover events that take place in nearby intervals. Recent data in humans and mice also indicate the presenc...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/j.cell.2004.08.008