Modified synthesis of the peptidomimetic natriuretic peptide receptor-C antagonist M372049
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چکیده
منابع مشابه
Allotopic antagonism of the non-peptide atrial natriuretic peptide (ANP) antagonist HS-142-1 on natriuretic peptide receptor NPR-A.
The microbial polysaccharide HS-142-1 has been documented as an antagonist of natriuretic peptides. It inhibits activation and peptide binding to both guanylate receptors natriuretic peptide receptor (NPR)-A and NPR-B, but has no effect on the non-cyclase receptor NPR-C. At first sight the effect of HS-142-1 on peptide binding appears to be surmountable, suggesting that it might be competitive ...
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We investigated whether natriuretic peptide (NP) acts as an endogenous antipyretic inside and/or outside the blood-brain barrier in rats made febrile by systemic administration of bacterial endotoxin (lipopolysaccharide; LPS). Intravenous (i.v.) injection of LPS induced a triphasic fever, the second phase of which was significantly enhanced by an i.v. injection of the NP receptor (A-type and B-...
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This study was undertaken to determine whether atrial natriuretic peptide (ANP)-, C-type natriuretic peptide (CNP)-, and nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathways exist in the rat retina. Exposure of the retina to ANP (10(-7)M), CNP (10(-7)M), S-nitroso-N-acetylpenicillamine (10(-5)M, SNAP; a NO doner), A23187 (10(-5)M; a Ca2+ionophore), and carbachol (10(-5)M) caused 1.4...
متن کاملUrinary C-Type Natriuretic Peptide
Cardiorenal Research La , Rochester, Minnesota; a innesota. This work was O1 HL36634 and PO1 H tional Research (grant no lingham, Ms. Heublein, D the use of urinary C-type hey have no relationships pt received November 13 cepted December 5, 2012 his study was conducted to determine whether urinary excretion of C-type natriuretic peptide (CNP) is elevated in acute decompensated heart failure (AD...
متن کاملThe C2238 Atrial Natriuretic Peptide Molecular Variant is Associated with Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling
IRCCS Neuromed, Pozzilli, Italy; William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, London, UK; Cardiovascular Center OLV Hospital, Aalst, Belgium; Dept. of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy; Dept. of Pharmacological and Biomolecular Sciences, University of Milan; and Dept...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2020
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2020.151654