Modified lung ultrasound score predicts ventilation requirements in neonatal respiratory distress syndrome

Abstract Background We propose a modified lung ultrasound (LUS) score in neonates with respiratory distress syndrome (RDS), which includes posterior instead of lateral fields, and 5-grade rating scale 4-grade scale. The purpose this study was to evaluate the reproducibility its correlation blood oxygenation assess ability early post-birth scans predict mode support on day life 3 (DOL 3). As secondary objective, weight overall LUS assessed. Methods analyzed 619 serial performed 70 preterm infants < 32 weeks gestation birth 1500 g. Assessments were within 24 h (LUS 0 ) days 2, 3, 5, 7, 10, 14, 21 28. scores correlated oxygen saturation over fraction inspired (S/F) support. Interrater agreement determined intraclass coefficient (ICC) Cronbach’s alpha. Probabilities need for various modes DOL assessed ordinal logistic regression. Least square (ls) means anterior pulmonary field compared. Results significantly S/F (Spearman rho = ?0.635; p 0.0001) had excellent interrater (ICC 0.94, 95% CI 0.93–0.95; alpha 0.99). Significant predictors ventilation requirements ( 0.016) (BW) 0.001). In ROC analysis, high reliability prognosing invasive (AUC 0.845 (95% DeLong CI: 0.738–0.951; 0.001)). Invasive most likely scores: ?7 (in BW 900 g), ? 10 1050 g) 15 1280 g). Posterior fields exhibited higher average than fields. Respective ls (confidence levels) 4.0 (3.8–4.1) vs. 2.2 (2.0–2.4); 0.001. Conclusions Post-birth predicts 3. Scores have predominant score.