Modification of primary and recurrent genital herpes in guinea pigs by passive immunization
نویسندگان
چکیده
منابع مشابه
Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs
Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mount...
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In a previous paper (Hirose et al., 1962) it was reported that guinea pigs highly immunized against a bacterial suspension of Corynebacterium diphtheriae resisted to a challenge by the conjunctival method (Murata et al., 1959) with a toxinogenic virulent strain without even traces of antitoxic immunity, while a passive transfer of the immunity failed. The reason for this failure may have been d...
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The goal of our study was to determine whether recombinant interleukin-2 (rIL-2) could modify the recurrence pattern of chronic herpes simplex virus type 2 (HSV-2) genital infection in guinea pigs. Animals that developed symptomatic acute HSV-2 infection were distributed at 14 days after viral inoculation into several treatment groups, which were similar with respect to the severity of acute di...
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In this report, a 32 year-old patient is reported who was suffering from recurrent genital herpes for 3 years and her disease could not be controlled with conventional treatment methods. But, application of Imiquimod 5% cream, 3 times a week for 3 months, proved very effective with no recurrence for up to 7 months. Since recurrent genital herpes is the result of some immunologic dysfunctions ca...
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The efficacy of passive immunization as a postexposure prophylactic measure for treatment of guinea pigs intranasally infected with Bacillus anthracis spores was evaluated. Antisera directed either against the lethal toxin components (PA or LF) or against a toxinogenic strain (Sterne) were used for this evaluation. All antisera exhibited high enzyme-linked immunosorbent assay titers against the...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2002
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-83-11-2797