MODENA: a multi-objective RNA inverse folding
نویسندگان
چکیده
منابع مشابه
MODENA: a multi-objective RNA inverse folding
Artificially synthesized RNA molecules have recently come under study since such molecules have a potential for creating a variety of novel functional molecules. When designing artificial RNA sequences, secondary structure should be taken into account since functions of noncoding RNAs strongly depend on their structure. RNA inverse folding is a methodology for computationally exploring the RNA ...
متن کاملInverse RNA folding solution based on multi-objective genetic algorithm and Gibbs sampling method
In living systems, RNAs play important biological functions. The functional form of an RNA frequently requires a specific tertiary structure. The scaffold for this structure is provided by secondary structural elements that are hydrogen bonds within the molecule. Here, we concentrate on the inverse RNA folding problem. In this problem, an RNA secondary structure is given as a target structure a...
متن کاملInverse folding of RNA
The aim of the inverse folding problem for RNA is, given a target structure like e.g. the one depicted in Fig. 1, find a sequence that folds into this structure. In this project we will exclusively focus on the secondary structure. The main driving force behind RNA structure formation is the creation of base pairs similar to the ones observed in the DNA double helical structure. In RNA thymine ...
متن کاملInverse folding of RNA II
In the Oxford Summer School in Computational Biology 2011, one of the projects was aimed at creating an improved method for inverse RNA folding based on a genetic algorithm (GA) approach. This turned out to be sufficiently successful [16] and inspiring, that we will extend on it in this year’s summer school. The inverse RNA folding problem consists of finding an RNA sequence that, as a molecule...
متن کاملINFO-RNA - a fast approach to inverse RNA folding
MOTIVATION The structure of RNA molecules is often crucial for their function. Therefore, secondary structure prediction has gained much interest. Here, we consider the inverse RNA folding problem, which means designing RNA sequences that fold into a given structure. RESULTS We introduce a new algorithm for the inverse folding problem (INFO-RNA) that consists of two parts; a dynamic programmi...
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ژورنال
عنوان ژورنال: Advances and Applications in Bioinformatics and Chemistry
سال: 2010
ISSN: 1178-6949
DOI: 10.2147/aabc.s14335