Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex

Neuroplasticity is essential to learning and memory in the brain; it has therefore also been implicated numerous neurological psychiatric disorders, making measuring state of neuroplasticity foremost importance clinical neuroscience. Long-term potentiation (LTP) a key mechanism studied extensively, invasively non-human animals. Translation human application largely relies on validation non-invasive measures LTP. The current study presents generative thalamocortical computational model visual cortex for investigating replicating interlaminar connectivity changes using EEG recording humans. combined with commonly used sensory LTP paradigm fit empirical data dynamic causal modelling. demonstrated remarkable accuracy recapitulating post-tetanus seen invasive research, including increased excitatory from thalamus layer IV II/III, established major sites cortex. These findings provide justification implementation presented ERP detail nature that underlie induced Future applications include translating rodent research humans concerning deficits may disease.