Modelling RNA folding under mechanical tension
نویسندگان
چکیده
منابع مشابه
Modelling RNA folding under mechanical tension.
We investigate the thermodynamics and kinetics of RNA unfolding and refolding under mechanical tension. The hierarchical nature of RNA structure and the existence of thermodynamic parameters for base pair formation based on nearest-neighbour interactions allows modelling of sequence-dependent folding dynamics for any secondary structure. We calculate experimental observables such as the transit...
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The Lässig-Wiese (LW) field theory for the freezing transition of random RNA secondary structures is generalized to the situation of an external force. We find a second-order phase transition at a critical applied force f = fc. For f < fc forces are irrelevant. For f > fc, the extension L as a function of pulling force f scales as L(f) ∼ (f − fc) 1/γ−1. The exponent γ is calculated in an ǫ-expa...
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Non-coding RNA sequences play a great role in controlling a number of cellular functions, thus raising the need to understand their complex conformational dynamics in quantitative detail. In this perspective, we first show that single molecule pulling when combined with with theory and simulations can be used to quantitatively explore the folding landscape of nucleic acid hairpins, and riboswit...
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We study the force-induced unfolding of random disordered RNA or single-stranded DNA polymers. The system undergoes a second-order phase transition from a collapsed globular phase at low forces to an extensive necklace phase with a macroscopic end-to-end distance at high forces. At low temperatures, the sequence inhomogeneities modify the critical behaviour. We provide numerical evidence for th...
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ژورنال
عنوان ژورنال: Molecular Physics
سال: 2006
ISSN: 0026-8976,1362-3028
DOI: 10.1080/00268970500525986