Modelling of end-product inhibition in fermentation

Microbial conversions are generally inhibited by their products. This product inhibition is particularly dependent on the product’s hydrophobicity and its acid dissociation behaviour, hence pH. Dependence microbial strain relatively modest according to many published data. Since has various mechanistic backgrounds, one requires an empirical model for simulation of fermentation processes. For obtaining a modelling framework that consistent bioreactor operation modes, literature data glucose ethanol were used elaborate simple case. The Pirt equation hyperbolic substrate uptake with three parameters depend linearly inhibiting concentration. type should facilitate model-based optimization operation.