Modelling biphasic hormetic dose responses to predict sub-NOAEL effects using plant biology as an example

Perception of hormesis as a significant dose–response phenomenon is found in many sciences without predicting and/or quantifying this low-dose effect with statistical models. Only minority papers published on plant biology or other apply available modelling the relationships, along significance testing for and prediction sub-NOAEL quantities. The threshold quantities opens further evaluation options such risk assessment, mixtures groups, selective populations, assessment transgenerational hormesis. Therefore, value research can benefit significantly from sound biphasic phenomenon. This review meant to raise awareness scientists modelling. • Hormesis more favorable than single hormetic doses. diversity only be captured represented through Available models adequately capture various experimental contexts. Prediction thresholds requires paves way sophisticated evaluations.