Modeling Temperature-Dependent Dermal Absorption and Clearance for Transdermal and Topical Drug Applications
نویسندگان
چکیده
منابع مشابه
Pharmaceutical Nanoemulsions and Their Potential Topical and Transdermal Applications
Topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. Nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, th...
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It has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be enhanced, e.g. by an increase in thermodynamic activity, supersaturation and penetration modifiers. Furthermore, dermal and transdermal delivery can be influenced by the interac...
متن کاملpharmaceutical nanoemulsions and their potential topical and transdermal applications
topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the abil...
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Abstact: Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost layer, the epidermis, which safeguards against chemical, microbial, and physical attack. The exceptional barrier properties of the skin result in it being...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2020
ISSN: 1550-7416
DOI: 10.1208/s12248-020-00451-2