Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes

Developing effective therapeutics or preventive interventions for important health threats is greatly enhanced whenever accessible models can enable the assessment of clinically outcomes. While no non-human model ever perfect, inexpensive in vivo small animal such as mice are often great help assessing relevant efficacy potential interventions. In addition to acute diarrhea, long-term growth and developmental effects enteric infections, with without overt increasingly recognized. To address these diverse effects, proving be very helpful. Herein, we review major clinical concerns parasitic bacterial infections that extremely common worldwide, especially vulnerable young children living impoverished areas, recently published murine their We find dietary deficiencies seen developing areas have striking on diarrhea enteropathy outcomes mice. However, differ different pathogens. Specifically, protein zinc deficiency considerably protozoal pathogens, suggesting pathogenetic pathways intervention effects. The pathogens reviewed seven top children, namely, Cryptosporidium, Giardia, Campylobacter, Shigella, enterotoxigenic Escherichia coli (ETEC), enteroaggregative E. (EAEC), enteropathogenic (EPEC).