Modeling dermatophytosis: Guinea pig skin explants represent a highly suitable model to study Trichophyton benhamiae infections
نویسندگان
چکیده
منابع مشابه
Efficacy of NVC-422 in the treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model.
OBJECTIVES Dermatophytes, belonging to genera including Trichophyton, Epidermophyton, and Microsporum, are the causative agents of superficial fungal infections, prevalences of which are estimated to be as high as 25% in the worldwide population. This study evaluated the activity of topical formulations of NVC-422 (sodium 2-[dichloroamino]-2-methylpropane-1-sulfonate), the lead compound in a ne...
متن کاملEffect of storage temperature on viability of Trichophyton mentagrophytes in infected guinea pig skin scales.
The effect of storage temperature on the viability of Trichophyton mentagrophytes in infected guinea pig skin scales was quantitatively evaluated for 182 days. Infected skin scales were stored, while protected from light, in glass containers with desiccant at four temperatures and sampled after saline treatment at various time intervals. No decrease in viability was observed for storage at 4 de...
متن کاملDermatophytosis, Microsporum canis, Trichophyton mentagrophytes, Microsporum gypseum
Overview: The fungal skin disease dermatophytosis has come to be called ringworm because of the appearance of the skin lesion that characteristically occurs with this disorder: a circular area of hair loss with a red, raised outer rim. These lesions result from an inflammatory reaction to the fungus. Most often, dogs and cats are infected by the Microsporum canis fungus, but other types of fung...
متن کاملTrichophyton rubrum: The Commonest Isolate from Dermatophytosis
Dermatophytosis is a trivial disease but has lot of psychological effect and a costly disease in terms of treatment. Though various species of dermatophytes produce clinically characteristic lesions, but a single species may produce variety of lesions depending upon site of infection. The present study was undertaken with following aim and objectives. Isolation and identification of different e...
متن کاملTargeted gene deletion and in vivo analysis of putative virulence gene function in the pathogenic dermatophyte Arthroderma benhamiae.
Dermatophytes cause the majority of superficial mycoses in humans and animals. However, little is known about the pathogenicity of this specialized group of filamentous fungi, for which molecular research has been limited thus far. During experimental infection of guinea pigs by the human pathogenic dermatophyte Arthroderma benhamiae, we recently detected the activation of the fungal gene encod...
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ژورنال
عنوان ژورنال: The Journal of Dermatology
سال: 2019
ISSN: 0385-2407,1346-8138
DOI: 10.1111/1346-8138.15150