Model‐guided combinatorial optimization of complex synthetic gene networks
نویسندگان
چکیده
منابع مشابه
Model‐guided combinatorial optimization of complex synthetic gene networks
Constructing gene circuits that satisfy quantitative performance criteria has been a long-standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three-gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in the phase space of sensor genetic composition. We generate a library of sensor circuits using diverse geneti...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2016
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20167265