Model Organisms and Systems in Life Sciences
نویسندگان
چکیده
Approximately 6-7% of newborns have congenital anomalies. The causes these anomalies are genetic-based, environmental, or multifactorial. cause almost 50% is not fully known. There many specific birth defects as part the syndromes. Even though syndromes complex, they use common signaling pathways in developmental process. Because complex nature disorders, different types model systems necessary to understand molecular pathogenesis diseases. infrastructure diseases and problems a process revealed with systems. While studying development multicellular organisms, related cellular processes examined. conducting studies, organoids, computerized (in silico) models used. Each method has its advantages disadvantages. In this review, we will provide recent knowledge on disadvantages modeling used processes.
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ژورنال
عنوان ژورنال: Cumhuriyet Üniversitesi T?p Fakültesi dergisi
سال: 2022
ISSN: ['1305-0028', '1300-1957']
DOI: https://doi.org/10.7197/cmj.991430