Model-Informed Precision Dosing Software Tools for Dosage Regimen Individualization: A Scoping Review

Background: Pharmacokinetic nomograms, equations, and software are considered the main tools available for Therapeutic Drug Monitoring (TDM). Model-informed precision dosing (MIPD) is an advanced discipline of TDM that allows dose individualization, requires a knowledge integration statistical calculations. Due to its extensive applicability, use these widespread in clinical practice. However, currently evidence on remains scarce. Objectives: To review summarize MIPD facilitate identification, evaluation, selection by users. Methods: An electronic literature search was conducted MEDLINE, EMBASE, OpenAIRE, BASE before July 2022. The PRISMA-ScR applied. inclusion criteria were studies focused developing practice, research, or modelling. Results: Twenty-eight classified as software. Ten unavailable. remaining 18 described depth. It noteworthy all used Bayesian methods estimate drug exposure provided population model default, except NONMEN. Conclusions: have become relevant TDM. been compared, facilitating it would be interesting standardize quality validate tools.