Model for hand-over-hand motion of molecular motors
نویسندگان
چکیده
منابع مشابه
A model for hand-over-hand motion of molecular motors
The dynamics of molecular motors is an important topic in biophysics and nanotechnology. In the living and in the artificial nanoscale world fast non-diffusive directed transport or rotary motion constitute key ingredients of any complex structure. Molecular motors are the “nanomachines” which perform these tasks [1, 2, 3, 4]. This definition involves a considerable amount of different molecule...
متن کاملModel for hand-over-hand motion of molecular motors.
A simple flashing ratchet model in two dimensions is proposed to simulate the hand-over-hand motion of two head molecular motors such as kinesin. Extensive Langevin simulations of the model are performed. Good qualitative agreement with the expected behavior is observed. We discuss different regimes of motion and efficiency depending on model parameters.
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Kinesin is a processive motor that takes 8.3-nm center-of-mass steps along microtubules for each adenosine triphosphate hydrolyzed. Whether kinesin moves by a "hand-over-hand" or an "inchworm" model has been controversial. We have labeled a single head of the kinesin dimer with a Cy3 fluorophore and localized the position of the dye to within 2 nm before and after a step. We observed that singl...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2008
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.77.031915