Mobile genetic elements in Clostridium difficile and their role in genome function
نویسندگان
چکیده
منابع مشابه
Mobile genetic elements in Clostridium difficile and their role in genome function
Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains ...
متن کاملGenetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile
BACKGROUND Clostridium difficile is the leading cause of hospital-associated diarrhoea in the US and Europe. Recently the incidence of C. difficile-associated disease has risen dramatically and concomitantly with the emergence of 'hypervirulent' strains associated with more severe disease and increased mortality. C. difficile contains numerous mobile genetic elements, resulting in the potential...
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ژورنال
عنوان ژورنال: Research in Microbiology
سال: 2015
ISSN: 0923-2508
DOI: 10.1016/j.resmic.2014.12.005