mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide
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منابع مشابه
Correction: mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide
[This corrects the article DOI: 10.1371/journal.pgen.1006974.].
متن کاملmlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide
Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker's yeast 60 new mlh3 alleles. Five alleles specifically disrupted MMR, whereas one (mlh3-32) specifically disrupted meiotic crossing...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2017
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1006974