منابع مشابه
A comprehensive in silico analysis of pathogenic nsSNPs in the NT5C2 gene involved in relapsed ALL
Background: About 10-20% of children suffering from acute lymphoblastic leukemia (ALL), experience a relapse, which is a major cause of their death. Purine nucleotide analogs are frequently prescribed to maintain the treatment of ALL. Cytosolic 5´-nucleotidase (NT5C2) catalyzes the 5´ dephosphorylation of purine analogs. Gain-of-function mutations in the NT5C2 gene result in resistance to the t...
متن کاملFunctional Assessment of CODM Gene in Different Cultivar of Papaveraceous Species Via In Silico Analysis
Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...
متن کاملFunctional Assessment of CODM Gene in Different Cultivar of Papaveraceous Species Via In Silico Analysis
Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...
متن کاملspo11-c631t gene polymorphism: association with male infertility and an in silico-analysis
objective: to investigate the association of c631t single nucleotide polymorphisms in spo11 gene with male infertilityfollowed by an in silico approach. spo11 is a gene involved in meiosis and spermatogenesis process, which in humans, this gene is located on chromosome 20 (20q13.2-13.3) with 13 exons. materials and methods: in a case-control study, 200 blood samples were collected from the ivf ...
متن کاملAn Efficient Method for Dynamic Analysis of Gene Regulatory Networks and in silico Gene Perturbation Experiments
With the increasing availability of experimental data on gene-gene and protein-protein interactions, modeling of gene regulatory networks has gained a special attention lately.Tohave abetter understanding of these networks it is necessary to capture their dynamical properties, by computing its steady states. Various methods have been proposed to compute steady states but almost all of them suff...
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ژورنال
عنوان ژورنال: Journal of Computational Biology and Bioinformatics Research
سال: 2013
ISSN: 2141-2227
DOI: 10.5897/jcbbr12.012