منابع مشابه
Mixed-phenotypic acute leukemia: cytochemically myeloid and phenotypically early T-cell precursor acute lymphoblastic leukemia
TO THE EDITOR: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is characterized by the specific immunophenotype of CD1a, CD8, and CD5 with stem cell or myeloid marker expression. This leukemia presents a particular flow cytometric diagnostic challenge, as it frequently exhibits sufficient myeloid-lineage differentiation to be classified as mixed-phenotype acute leukemia (MPAL). Th...
متن کاملA Biphenotypic (Mixed Phenotypic) Acute Leukemia: Report of Two Cases with Immunophenotypic Study
Biphenotypic acute leukemia (BAL) is an uncommon clinical entity. It is a type of acute leukemia with features characteristic of both the myeloid and lymphoid lineages and for this reason is designated as mixed-lineage, hybrid or biphenotypic acute leukemia. As strict diagnostic criteria have only recently been established, the precise incidence among acute leukemia is uncertain, although it is...
متن کاملHow I treat mixed-phenotype acute leukemia.
Mixed-phenotype acute leukemia (MPAL) encompasses a heterogeneous group of rare leukemias in which assigning a single lineage of origin is not possible. A variety of different terms and classification systems have been used historically to describe this entity. MPAL is currently defined by a limited set of lineage-specific markers proposed in the 2008 World Health Organization monograph on clas...
متن کاملClinical relevance of acute mixed-lineage leukemia.
A recent report by Pui et all focused on the biologic and clinical relevance of acute mixed-lineage leukemia; namely, acute lymphoblastic leukemia expressing myeloid-associated antigens (My+ ALL) and acute myeloid antigens expressing lymphoid antigens (Ly+ AML) were analyzed in a pediatric series. In our opinion, a major point in the field of hybrid acute leukemia remaining undetermined is whic...
متن کاملMixed-phenotype acute leukemia (MPAL) and beyond
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Mixed-phenotype acute leukemia (MPAL) is a rare but difficult to treat hematologic malignancy with immuno-phenotypic co-expression of at least two cell lineages, or with only rare cases involving all three lineages, e.g. myeloid with B-or T-lymphoid or all t...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2018
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2017.1400317