Mitonuclear linkage disequilibrium in human populations
نویسندگان
چکیده
منابع مشابه
Mitonuclear linkage disequilibrium in human populations.
There is extensive evidence from model systems that disrupting associations between co-adapted mitochondrial and nuclear genotypes can lead to deleterious and even lethal consequences. While it is tempting to extrapolate from these observations and make inferences about the human-health effects of altering mitonuclear associations, the importance of such associations may vary greatly among spec...
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MEDICAL SCIENCES. For the article ‘‘Linkage disequilibrium in human populations,’’ by Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton, which appeared in issue 10, May 13, 2003, of Proc. Natl. Acad. Sci. USA (100, 6069–6074; First Published April 29, 2003; 10.1073 pnas.1031521100), due to a printer’s error, the last three col...
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The linkage disequilibrium in a subdivided populaton is shown to be equal to the sum of the average linkage disequilibrium for all subpopulations and the covariance between gene frequencies of the loci concerned. Thus, in a subdivided population the linkage disequilibrium may not be 0 even if the linkage disequilibrium in each subpopulation is 0. If a population is divided into two subpopulatio...
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The extent of linkage disequilibrium (LD) was studied in two small food-gathering populations-Evenki and Saami-and two larger food-producing populations-Finns and Swedes-in northern Eurasia. In total, 50 single-nucleotide polymorphisms (SNPs) from five genes were genotyped using real-time pyrophosphate DNA sequencing, whereas 14 microsatellites were genotyped in two X-chromosomal regions. In ad...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society B: Biological Sciences
سال: 2015
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2015.1704