Mitogenic stimulation of human lymphocytes byPseudomonas aeruginosagalactosephilic lectins
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Release of arachidonic acid from human lymphocytes in response to mitogenic lectins
After exposure to mitogenic lectins in vitro, human mononuclear cells (95% lymphocytes) that had been prelabeled with [14C]arachidonic acid rapidly released a portion of their radioactivity in the medium. Most of the released radioactivity was demonstrated to be free arachidonic acid. Although other sources are not excluded, the most important source of cell-bound radioactivity in the release r...
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Tumor-infiltrating lymphocytes (TILs) have shown in vivo antitumor efficacy in both animal and human studies. Functions thought necessary for antitumor activity include cytolysis, homing, and proliferation at tumor sites. TILs, which are T lymphocytes grown ex vivo directly from tumors, bear interleukin 2 (IL-2) receptors capable of transducing the IL-2 mitogenic signal. However, IL-2 is not no...
متن کاملMembrane potential changes during mitogenic stimulation of mouse spleen lymphocytes.
By monitoring differences in accumulation of the lipophilic cation [(3)H]tetraphenylphosphonium in media containing low or high potassium concentrations [Lichtshtein, D., Kaback, H. R. & Blume, A. J. (1979) Proc. Natl. Acad. Sci. USA 76, 650-654], the membrane potential of lymphocytes from various sources has been estimated. On the basis of this method, the potential of normal mouse spleen lymp...
متن کاملCalcium ion influx during mitogenic stimulation of lymphocytes.
The uptake of free calcium ion (Ca2+) in PHA- or A23187-stimulated lymphocytes was measured using 45CaCl2 and 3H-water. Augmentation of Ca2+ uptake by both mitogens was observed, but the enhanced uptake occurred transiently, sometime within 30 min of the stimulation. The total amount of calcium in quiescent lymphocytes as determined by atomic absorption spectroscopy was about 2.9 X 10(-15) g/ce...
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Bestimmte Agglutinine aus Pflanzen (Lektine) beanspruchen deswegen besonderes Interesse, weil sie neben erythrozytenagglutinierenden Eigenschaften auch die Fähigkeit besitzen, Leukozyten oder Organund Tumorzellen erfassen zu können und außerdem noch mitogene und cytotoxische Wirkung entfalten. Diese Eigenschaften können Bestandteil eines einzigen Agglutininmoleküls sein, es ist aber auch durcha...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1979
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1979.tb03319.x