Mitochondrial replacement therapy and the “three parent baby”

Mito-nuclear Incompatibilities and Mitochondrial Replacement Therapy

Mitochondrial replacement therapy (MRT) is a human reproductive technology by which the mitochondria of a recipient’s eggs are effectively replaced by those of a donor, potentially eliminating harmful mitochondrial mutations carried by the recipient. However, concerns have been raised that MRT may lead to problems due to incompatibilities between the nuclear genome of the recipient and mitochon...

Mitochondrial replacement therapy: the UK and US regulatory landscapes

Mitochondrial replacement therapy: Cautiously replace the master manipulator.

Around 1 in 200 children born each year have mutations in the mitochondrial DNA (mtDNA)—the genome of the cellular powerhouse. In most cases this causes only mild disease, often without any symptoms. However, for about 1 in 6,500 individuals, mitochondrial disease causes serious and often fatal conditions, which include blindness, muscular weakness, and heart failure. Currently available therap...

Three-dimensional model of surfactant replacement therapy.

Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respiratory distress syndrome (ARDS), early successes were followed by failures. This un...

the american dream in three plays by eugene oneill, tennessee williams, and lorraine hansberry

این مطالعه به نقد و بررسی مفهوم اسطوره ی رویای امریکایی در سه نمایشنامه ی قرن بیستم امریکایی می پردازد، که این نمایشنامه ها عبارتند از: the iceman cometh (مرد یخین می آید) نوشته ی یوجین اونیل، 1940؛ desirea streetcar named (اتوبوسی به نام هوس) نوشته ی تنسی ویلیامز، 1947؛ و in the sun raisin a (انگور خشکیده در آفتاب) ، نوشته ی لورین هنزبری، 1958. هدف از این بررسی، ابتدا شناخت مفهوم رویای امری...