منابع مشابه
Mitochondrial Morphology
single-peaked, tuned receptor. After allowing for the above errors, I interpret Hillman's response as a claim that my hierarchical ordering of the tuned receptor as one part of traditional color theory was inappropriate and misleading. Indeed, Hillman says that: "The essence of the PalmerYoung paradigm . . . has nothing to do [italics mine] with the shape or narrowness of these curves." This as...
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Proper positioning of mitochondria is critical for cellular function. Mitochondria localization close to synapses regulates signalling at neuronal and immune synapses (ISs). Vice versa, synapses influence activity, motility and the fusion/fission balance of close-by mitochondria. In this issue of The EMBO Journal, Baixauli et al (2011) identify a role for the mitochondrial fission factor dynami...
متن کاملDrosophila Porin/VDAC Affects Mitochondrial Morphology
Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca(2+) overload, oxidative stress and Bax-Bid activation. To confirm this hypothesis in vivo, we generated and characterized Drosophila VDAC (porin) mutants and found that Porin is not required for mitochondrial apoptosis, which is consistent with the previous mouse studie...
متن کاملMitochondrial morphology and distribution in mammalian cells.
It is now appreciated that mitochondria form tubular networks that adapt to the requirements of the cell by undergoing changes in their shape through fission and fusion. Proper mitochondrial distribution also appears to be required for ATP delivery and calcium regulation, and, in some cases, for cell development. While we now realise the great importance of mitochondria for the cell, we are onl...
متن کاملTitle : Abnormal mitochondrial transport and morphology as
Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival motor neuron 1 (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a ubiquitously expressed protein, leads to spinal motor neuron-specific degeneration in SMA patients remains unknown. In this study, we examined the role of S...
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ژورنال
عنوان ژورنال: Science
سال: 1974
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.185.4151.630