Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both

Editorial Commentary Endothelial Dysfunction and Hypertension Cause or Effect?

Endothelial dysfunction refers to impairment of endothelium-dependent vasodilatation and implies widespread abnormalities in endothelial integrity and homeostasis. The ability to assess endothelial function has been critical to advancing our understanding of the significance of this complex monolayer to cardiovascular (CV) disease. Early human translational approaches required invasive assessme...

Exceptional exporter performance : cause , effect , or both ?

A growing body of empirical work has documented the superior performance characteristics of exporting plants and firms relative to non-exporters. Employment, shipments, wages, productivity and capital intensity are all higher at exporters at any given moment. This paper asks whether good firms become exporters or whether exporting improves firm performance. The evidence is quite clear on one po...

Angiopoietin-1 and pulmonary hypertension: cause or cure?

Microvessel mechanobiology in pulmonary arterial hypertension: cause and effect.

P ulmonary arterial hypertension (PAH, or group 1 pulmonary hypertension) is a progressive, insidious, and fatal illness of the pulmonary microvasculature. Proliferative remodeling of the small resistance arteries results in an elevation of mean pulmonary arterial pressure (mPAP) and total pulmonary vascular resistance (PVR), increasing the workload on the right ventricle (RV) until it eventual...

Chicken or the egg: Warburg effect and mitochondrial dysfunction

Compared with normal cells, cancer cells show alterations in many cellular processes, including energy metabolism. Studies on cancer metabolism started with Otto Warburg's observation at the beginning of the last century. According to Warburg, cancer cells rely on glycolysis more than mitochondrial respiration for energy production. Considering that glycolysis yields much less energy compared w...