Mitochondrial Dysfunction and Age - related Oocyte Quality
نویسندگان
چکیده
منابع مشابه
Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss
Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, t...
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In humans, the fertility in female declines slowly from the age of 30 years [1,2]. Embryo implanting ability and survival start declining gradually after 30 years of age, but by more than two thirds after 40 years and in younger women with reduced ovarian reserve [3]. While decline in the frequency of intercourse is one of the reasons, reduction in the quality of either the embryos arising from...
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The prevalence of cardiovascular diseases is significantly increased in the older population. Risk factors and predictors of future cardiovascular events such as hypertension, atherosclerosis, or diabetes are observed with higher frequency in elderly individuals. A major determinant of vascular aging is endothelial dysfunction, characterized by impaired endothelium-dependent signaling processes...
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Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased...
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ژورنال
عنوان ژورنال: Reproductive and Developmental Medicine
سال: 2017
ISSN: 2096-2924
DOI: 10.4103/2096-2924.210693