Mitochondrial DNA copy number in cumulus cells is a strong predictor of obtaining good-quality embryos after IVF
نویسندگان
چکیده
منابع مشابه
Assessment of mitochondrial DNA copy number in peripheral blood leukocyte of opiate abusers and healthy individuals
Background: Based on the studies, variation in the mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes is associated with increased susceptibility to diseases including cancer. Opiate abusers are at high risk for diseases. In this study, we measured the mtDNA copy number in peripheral blood leukocytes in a group of opiate abusers compared with those in healthy individuals. Met...
متن کاملKeratoconus is associated with increased copy number of mitochondrial DNA
PURPOSE To investigate the possible association of oxidative stress with keratoconus (KC), we estimated the changes in relative mitochondrial DNA (mtDNA) content. METHODS The study included 119 patients with KC and 208 controls matched for gender, ethnicity, and systemic disease status. We selected controls who were older than the patients since the mtDNA copy number tends to increase with ag...
متن کاملMitochondrial DNA Copy Number Is Associated with Breast Cancer Risk
Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples...
متن کاملThe mitochondrial DNA content of cumulus granulosa cells is linked to embryo quality.
STUDY QUESTION Could the mitochondrial DNA (mtDNA) content of cumulus granulosa cells (CGCs) be related to oocyte competence? SUMMARY ANSWER The quality of embryos obtained during IVF procedures appears to be linked to mtDNA copy numbers in the CGCs. WHAT IS KNOWN ALREADY Oocyte quality is linked to oocyte mtDNA content in the human and other species, and the mtDNA copy number of the oocyte...
متن کاملHigh copy number of mitochondrial DNA (mtDNA) predicts good prognosis in glioma patients.
Alterations in mitochondrial DNA (mtDNA) copy number have been widely identified in many types of human cancers and are considered a common cancer hallmark. However, the prognostic value of altered mtDNA content in gliomas remains largely unknown. The aim of this study was to investigate mtDNA copy number in a cohort of gliomas (n = 124) and non-neoplastic brain tissues (control subjects; n = 2...
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ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2016
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-015-0621-0