Mitochondrial disorders and ASD. Mechanisms of mitochondrial dysfunction in ASD

Introduction ASD is a multifactorial disease. They arise from the interaction of various genetic and environmental factors. These factors affect specific neuronal circuits, oxidative stress, neuroinflammation, mitochondrial dysfunction. This disrupts development nervous system, formation synapses, connection between brain regions, size brain. Almost 80% patients with suffer Therefore, dysfunction plays crucial role in pathogenesis ASD. Objectives Deficiency adenosine-triphosphate (ATP) abnormal levels Reactive oxygen species (ROS) cause leads to metabolic disorders, disorders synaptic plasticity immune response Methods The negative association pathogenic mtDNA mutations IQ for children / MD. overall prevalence these abnormalities 1.2 times higher ASD, researchers reaffirm that autistic probands carry burden mtDNA, especially are prone deleterious effects on OXPHOS. According number researchers, all should be screened MD, given: high markers function compared control group; relatively MD ASD; some who have may phenotypically indistinguishable typical potential clinical significance Results Conclusions pathophysiological mechanisms multifactorial. largely unclear. But hypothesis being clarified. Mitochondrial has been identified as hallmark diseased neurons patients, suggesting critical allowing correction by normalizing functions. Disclosure Interest None Declared