Mitochondrial Disease and Stroke

Mitochondrial disease and stroke.

BACKGROUND AND PURPOSE It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients. Our purpose was to determine, in this prospective ongoing study, whether ischemic stroke is the only manifestation of a mitochondrial disorder in young patients. METHODS Patients aged </=50 years, admitted to the Stroke Unit from January 1999 to May 200...

mitochondrial genetics, disease and inheritance

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mitochondrial disease

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Mitochondrial Ceramide in Stroke

Function of mitochondrial complex-I and -IV in normal human and Parkinson's disease cybrids

Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...