Mitochondrial Deoxyribonucleic Acid 4977-bp Deletion is Associated with Diminished Fertility and Motility of Human Sperm1
نویسندگان
چکیده
منابع مشابه
Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity
Large deletions in mitochondrial DNA (mtDNA) may be involved in the pathogenesis of mitochondrial disease. In this study, we investigated the relationship between a 4,977-bp deletion in the mitochondrial genome (ΔmtDNA(4977)) and the severity of clinical symptoms in patients with mitochondrial disease lacking known point mutations. A total of 160 patients with mitochondrial disease and 101 heal...
متن کاملMitochondrial DNA content and 4977 bp deletion in unfertilized oocytes.
Previous studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp delet...
متن کاملMitochondrial DNA 4977 BP deletion mutations in lung carcinoma.
BACKGROUND The most common and also the most often assayed mtDNA deletion mutation, degrees mtDNA 4,977 sub has been demonstrated in various types of human cancer. However, knowledge about degrees mtDNA 4,977 in lung carcinoma is poor. AIM To study the 4,977 bp deletions of mitochondrial DNA ( degrees mtDNA 4,977) in lung cancer, adjacent histologically normal and normal lung tissue and its p...
متن کاملMitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age.
Mitochondrial DNA (mtDNA) is believed to be particularly susceptible to oxidative damage during aging, resulting in mtDNA point mutations, duplications, and deletions. Although mtDNA deletions have been reported in various human tissues, e.g., the brain, heart, and skeletal muscle, little is known about the occurrence in hair. Therefore, we screened for the presence of mtDNA 13162 bp, 10422 bp,...
متن کاملSensitive detection of the 4977-bp deletion in human mitochondrial DNA of young individuals.
Specific deletions in mitochondrial DNA (mtDNA) are present at high levels in skeletal muscle and other tissues (7). It has been suggested that an accumulation of these somatic deletions could be caused by oxidative damage that increases with age (2). In recent years, more than 20 different types of deletions have been identified using polymerase chain reaction (PCR) techniques (16). The most f...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1995
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod52.4.729