منابع مشابه
Assembly of the Mitochondrial Protein Import Channel
The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central β-barrel channel, Tom40, and six proteins with α-helical transmembrane segments. The precursor of Tom40 is imported from the cytosol by a pre-existing TOM complex and inserted into the outer membrane by the sorting and assembly machinery (SAM). Tom40 then assembles with α-helical Tom proteins to the matur...
متن کاملMitochondrial protein synthesis, import, and assembly.
The mitochondrion is arguably the most complex organelle in the budding yeast cell cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous compartment, the matrix, is bounded by the highly structured inner membrane, which in turn is bounded by the intermembrane space and the outer membrane. Approximately 1000 proteins are present in these organelles, of whi...
متن کاملMitochondrial protein import.
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of the precursor protein. Nucleoside triphosp...
متن کاملThe mitochondrial protein import apparatus.
INTRODUCTION ..................................................................................... 331 THE PRECURSOR PROTEINS .................................................................... 332 Targeting Signals ................................................................................. 332 Translocation Competence ........................................................................
متن کاملMechanisms of mitochondrial protein import.
Mitochondria import most of their proteins from the cytosol. Precursor forms of most matrix proteins as well as some IM and IMS proteins are synthesized on cytoplasmic ribosomes with N-terminal cleavable signal sequences. Many other mitochondrial proteins including IM carrier proteins contain internal targeting sequences. Three multisubunit translocases, one in the OM and two in the IM, partici...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 2004
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns2004342