Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
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منابع مشابه
Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
Gli transcription factors of the Hedgehog (Hh) pathway have been reported to be drivers of malignant mesothelioma (MMe) cell survival. The Gli inhibitor GANT61 induces apoptosis in various cancer cell models, and has been associated directly with Gli inhibition. However various chemotherapeutics can induce cell death through generation of reactive oxygen species (ROS) but whether ROS mediates G...
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متن کاملT cell apoptosis and reactive oxygen species.
process of activation, division, and differentiation to generate a large pool of activated effector T cells. Regulated induction of apoptosis of these expanded T cells avoids several problems for the host, including increased metabolic cost, disruption of lymphoid homeostasis, and predisposition to autoimmunity and lymphoid neoplasia. On the other hand, it is essential that some activated T cel...
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Copyright © 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/HYPERTENSIONAHA.109.130054 2009;53;885-892; originally published online Apr 27, 2009; Hypertension Francesco Addabbo, Monica Montagnani and Michael S. Goligorsky Mitochondria and Reactiv...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2729