Mitochondria are sources of metabolic sink and arrhythmias
نویسندگان
چکیده
منابع مشابه
Cardiac mitochondria and arrhythmias.
Despite a high prevalence of sudden cardiac death throughout the world, the mechanisms that lead to ventricular arrhythmias are not fully understood. Over the last 20 years, a growing body of evidence indicates that cardiac mitochondria are involved in the genesis of arrhythmia. In this review, we have attempted to describe the role that mitochondria play in altering the heart's electrical func...
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Sucrose, a glucose-fructose disaccharide, is the main sugar transported in the phloem of most plants and is the origin of most of the organic matter. Upon arrival in sink tissues, the sucrose must be cleaved by invertase or sucrose synthase. Both sucrose-cleaving enzymes yield free fructose, which must be phosphorylated by either fructokinase (FRK) or hexokinase (HXK). The affinity of FRK to fr...
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1 National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2 Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia; 3 St Vincent's Hospital Clinical School, University of New South Wales, Sydney, NSW, Australia; 4 Roche R&D Center (China) L...
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Relatively few investigations have been made on the oxidation of pyruvate by heart mitochondria. Guinea pig heart mitochondria (1) and rabbit heart cyclophorase preparations (2, 3) have been found to oxidize pyruvate, but in no case has a detailed investigation been made of the mechanisms involved and the requirements for the operation of the complete tricarboxylic acid cycle. On the other hand...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2011
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2011.04.005