Mismatch repair genes of eukaryotes

DNA Mismatch Repair in Eukaryotes and Bacteria

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as w...

Epimutation in DNA Mismatch Repair (MMR) Genes

DNA mismatch repair genes and colorectal cancer.

Polymorphism of DNA mismatch repair genes in endometrial cancer.

UNLABELLED Endometrial cancer (EC) is the second most common malignancy associated with hereditary non-polyposis colorectal cancer (HNPCC) family. The development of HNPCC is associated with defects in DNA mismatch repair (MMR) pathway resulting in microsatellite instability (MSI). MSI is present in a greater number of EC than can be accounted for by inherited MMR mutations, therefore alternati...

DNA Mismatch Repair (MMR) Genes and Endometrial Cancer