MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma

C5a Regulates NKT and NK Cell Functions

Imaging Case: NK/T-Cell Lymphoma, Nasal Type

Peripheral T-cell lymphomas are a group of heterogeneous disorders and according to WHO classification, are categorized into nodal and extranodal forms. NK/T-cell lymphoma, nasal type, is a subtype of extranodal peripheral T-cell lymphoma and commonly presents as a midfacial destructive lesion. This disorder is more prevalent in Asia and South America and has a strong association with Epstein B...

NKT Cell Responses to B Cell Lymphoma

Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells. NKT cells mediate tumor immune-surveillance; however, NKT cells are numerically reduced and functionally impaired in lymphoma patients. Many hematologic malignancies express CD1d molecules and co-stimulatory proteins needed to induce anti-tumor...

NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer

Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...

Blastic NK-Cell Leukemia / Lymphoma

Blastic natural killer (NK) cell lymphoma / leukemia is a rare NK cell malignancy of unknown etiology. It occurs in multiple sites and with a propensity for skin involvement. We report such a case in a 35-year-old male suffering from erythematous and purpuric papules and plaques on his face and trunk for 6 months. A biopsy specimen of the skin showed diffuse infiltration of blastlike lymphoid c...