MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy
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چکیده
منابع مشابه
MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...
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In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regio...
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UNLABELLED Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though the kidneys result in ...
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During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellu...
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In collaboration with the MIRD Committee, Society of Nuclear Medicine: E.E. Watson (Chair), J.S. Robertson (Task Group Leader), W.E. Bolch, A.B. Brill, N.D. Charkes, D.R. Fisher, M.T. Hays, R.W. Howell, J.A. Siegel, S.R. Thomas and B.W. Wessels Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida; Gaithersburg, Maryland; Department of Radiology, George...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2010
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.108.058651