miR‑106b‑5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells
نویسندگان
چکیده
منابع مشابه
Heterogeneous activation of p19 in pulmonary artery smooth muscle cells
Solodushko V, Alvarez DF, Viator R, Messerall T, Fouty B. Heterogeneous activation of p19 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300: L642–L647, 2011. First published January 7, 2011; doi:10.1152/ajplung.00117.2010.— p19 is a tumor suppressor that leads to cell cycle arrest or apoptosis by stabilizing p53. p19 is not critical for cell cycle regulation under ...
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p19(ARF) is a tumor suppressor that leads to cell cycle arrest or apoptosis by stabilizing p53. p19(ARF) is not critical for cell cycle regulation under normal conditions, but loss of p19(ARF) is seen in many human cancers, and a murine p19(Arf) knockout model leads to malignant proliferation and tumor formation; its role in controlling nonmalignant proliferation is less defined. To examine thi...
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Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors. Circulating ET-1 contributes to vascular remodeling by promoting SMC proliferation and migration and inhibiting SMC apoptosis. Although endothelial cells (EC) are the primary source of ET-1, whether ET-1 produced by SMC modulates pulmona...
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Right ventricular strain patterns on electrocardiogram such as right axis derivation and S1Q3T3 are well known for their diagnostic value in cases of acute pulmonary embolism. Nonetheless, these changes are not pathognomonic. We report a patient with electrocardiographic evidence of right ventricular strain secondary to an unusual etiology.
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Pulmonary hypertension is a significant cause of morbidity and mortality in infants. Historically, there has been significant study of the signaling pathways involved in vascular smooth muscle contraction in PASMC from fetal sheep. While sheep make an excellent model of term pulmonary hypertension, they are very expensive and lack the advantage of genetic manipulation found in mice. Conversely,...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2020
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2020.4532