MiR-33 connects cholesterol to the cell cycle
نویسندگان
چکیده
منابع مشابه
MiR-33 connects cholesterol to the cell cycle
MicroRnAs (miRnAs) are non-coding RnAs that downregulate gene expression at the post-transcriptional level. in recent years, their regulatory roles have been receiving much attention. MiR33 is one such miRnA, recently identified as a critical regulator of cholesterol homeostasis1 and insulin signaling.2 The recent study by Cirera-salinas et al.3 described a new role of miR33 for the regulation ...
متن کاملThe tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irre...
متن کاملAntagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.
Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism have revealed that miR-33, an intronic microRNA located within the SREBF2 gene, suppresses expression of the cholesterol transporter ABC transporter A1 (ABCA1) and lowers HDL levels. Conversely, mechanisms that in...
متن کاملSKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box
We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p, cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required for ubiquitin-mediated proteolysis of Cin2p, Clb5p, and the Cdk inhibitor Sic1p, and provides a lin...
متن کاملCholesterol Biosynthesis and Homeostasis in Regulation of the Cell Cycle
The cell cycle is a ubiquitous, multi-step process that is essential for growth and proliferation of cells. The role of membrane lipids in cell cycle regulation is not explored well, although a large number of cytoplasmic and nuclear regulators have been identified. We focus in this work on the role of membrane cholesterol in cell cycle regulation. In particular, we have explored the stringency...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.11.6.19786