miR-329 suppresses the growth and motility of neuroblastoma by targeting KDM1A
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MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC
Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known. Materials and Methods: Gastric cancer cell lines were cultured. Tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time PCR (qRT-PCR) analysis. The tissue microarrays (T...
متن کاملmir-493 suppresses the proliferation and invasion of gastric cancer cells by targeting rhoc
objective(s):mirnas have been proposed to be key regulators of tumorigenesis, progression and metastasis. however, their effect and prognostic value in gastric cancer is still poorly known. materials and methods: gastric cancer cell lines were cultured. tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time pcr (qrt-pcr) analysis. the tissue microarrays (tm...
متن کاملmir-329 restricts tumor growth by targeting grb2 in pancreatic cancer
Pancreatic cancer is one of the most lethal malignancies worldwide. To illustrate the pathogenic mechanism(s), we looked into the expression and function of miR-329 associated with pancreatic cancer development. It was found that miR-329 expression was downregulated in the pancreatic cancer patients who demonstrated significantly shorter overall survival than the patients having upregulated exp...
متن کاملMiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF)
Objective(s): To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and ...
متن کاملMiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1
BACKGROUND Increasing evidence has shown that microRNAs function as oncogenes or tumor suppressors in human malignancies, but the roles of miR-186 in human bladder cancer (BC) is still unclear. METHODS First, quantitative real-time PCR (qRT-PCR) was performed to detect miR-186 expression in bladder cancer tissues and cell lines. Then, Bioinformatics analysis, combined with luciferase reporter...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2013
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2013.11.036