MiR-19a mediates gluconeogenesis by targeting PTEN in hepatocytes
نویسندگان
چکیده
منابع مشابه
MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes
MiR-19a, a member of mir-17-92 microRNA clusters, has been demonstrated to promote cell proliferation and angiogenesis via regulating the PI3K/AKT pathway, the major insulin signaling pathway. However, whether miR-19a plays an important role in glycogen synthesis in hepatocytes remains unknown. Here, we define the impact of miR-19a on glycogen synthesis and IL-6-induced reduced glycogenesis in ...
متن کاملmiR-19a Promotes Cell Growth and Tumorigenesis by Targeting SOCS1 in Gastric Cancer
Gastric cancer is the fourth most common cancer and the second leading cause of global cancer mortality (Jemal et al., 2011). Despite great progress in surgical technique, diagnostic method and new chemotherapy regimens, no effective targeting therapy is available for gastric cancer (Shi et al., 2010). Thus, understanding the molecular mechanism underlying gastric cancer is still needed. MicroR...
متن کاملmiR-19a protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via PTEN/PI3K/p-Akt pathway
miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. The present study was to investigate the effect of miR-19a on myocardial ischem...
متن کاملmiR-382 targeting PTEN-Akt axis promotes liver regeneration.
Liver regeneration is a highly orchestrated process which can be regulated by microRNAs (miRNAs, miRs), though the mechanisms are largely unclear. This study was aimed to identify miRNAs responsible for hepatocyte proliferation during liver regeneration. Here we detected a marked elevation of miR-382 in the mouse liver at 48 hrs after partial hepatectomy (PH-48h) using microarray analysis and q...
متن کاملmiR-21-5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3
Drug resistance and disease recurrence are major obstacles to the effective treatment of cancer, including gastric cancer (GC). However, the mechanisms of drug resistance remain to be fully elucidated. The present study investigated the roles of microRNA (miR)‑21‑5p in the doxorubicin (DOX) resistance of GC cells and the underlying mechanisms. miR‑21‑5p expression levels were identified to be i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.8312