miR-199-sponge transgenic mice develop physiological cardiac hypertrophy
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چکیده
منابع مشابه
TNNI3K, a Cardiac-Specific Kinase, Promotes Physiological Cardiac Hypertrophy in Transgenic Mice
PURPOSE Protein kinase plays an essential role in controlling cardiac growth and hypertrophic remodeling. The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy. However, the precise function of TNNI3K in regulating cardiac remodeling has remained controversial. METHODS AND RESULTS In a rat model of cardiac hypertrophy...
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Cardiac hypertrophy is defined as an abnormal increase in heart muscle mass and is functionally, mechanistically, and histologically distinguished from normal embryonic and postnatal myocardial growth by characteristic changes in cardiac myocyte shape and volume.1 Reactive hypertrophy, that is, hypertrophy that occurs in response to an extrinsic increase in cardiac work,2 is distinguished from ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2016
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvw052