MiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case-control studies

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MiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case-control studies

Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then ...

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miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies.

Digestive tumors have the highest incidence among all tumor types worldwide. miR-146a has been shown to play an important role in the development, apoptosis, invasion and metastasis of digestive tumors. Additionally, a miR-146a gene polymorphism has been associated with the risk of a variety of cancer types in the digestive system. Therefore, in order to investigate the correlation, a meta-anal...

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Association of miR-146a rs2910164 polymorphism with squamous cell carcinoma risk: a meta-analysis.

PURPOSE Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of malignancies. Hence, the aim of this study was to investigate the association between this genetic variant and the susceptibility of squamous cell carcinoma (SCC). METHODS We performed a systematic search using PubMed, EMBASE, ISI Web of Science, Cochrane Central Regi...

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Association of pre-miR-146a rs2910164 polymorphism with the risk of head and neck cancer.

BACKGROUND Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility. The aim of the present study was to investigate the possible influence of the pre-miR-146a rs2910164 polymorphism on the risk of squamous cell carcinoma ...

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MiR-146a rs2910164 polymorphism is associated with hepatocellular carcinoma: a meta-analysis.

Results of published studies on the association between the miR-146a rs2910164 polymorphism and the risk of hepatocellular carcinoma (HCC) were inclusive. We performed a meta-analysis. A literature research was conducted using PubMed, Cochrane Library, Ovid, Embase, Wanfang and China National Knowledge Infrastructure (CNKI) databases, to identify studies. Statistical analyses were conducted in ...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2016

ISSN: 1949-2553

DOI: 10.18632/oncotarget.13599