miR-140-5p inhibits the proliferation, migration and invasion of vascular smooth muscle cells by suppressing the expression of NCKAP1

Introduction. The occurrence of aortic dissection is related to the proliferation and metastasis vascular smooth muscle cells. In our present study, we found that expression miR-140-5p was inhibited in wall abdominal aorta patients. However, mechanism development unclear. Material methods. We detected NCK Associated Protein 1 (NCKAP1) blood vessel patients normal people by PCR. Next, established overexpression inhibition cells (CRL-1999 cells). BrdU assays, wound healing assays transwell were performed detect invasion ability these Finally, luciferase reporter assay relationship between NCKAP1. Results. suppressed patients, levels NCKAP1 those tissues upregulated. Overexpression proliferation, migration targeted Conclusions. repressed targeting inhibiting Furthermore, results study suggest new strategies targets for clinical treatment arterial dissection.