miR-137: A New Player in Schizophrenia
نویسندگان
چکیده
منابع مشابه
miR-137: A New Player in Schizophrenia
Schizophrenia is a complex genetic disease and characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are critical to neurodevelopment and adult neuronal processes by modulating the activity of multiple genes within biological networks. MiR-137 as a brain-enriched microRNA, plays important roles in reg...
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The significant impact of microRNAs (miRNAs) on disease pathology is becoming increasingly evident. These small non-coding RNAs have the ability to post-transcriptionally silence the expression of thousands of genes. Therefore, dysregulation of even a single miRNA could confer a large polygenic effect. Schizophrenia is a genetically complex illness thought to involve multiple genes each contrib...
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Article history: Received 4 October 2016 Accepted 4 October 2016 Available online 5 October 2016 to schizophrenia and does this variant have any effect on its function? Computationalmethods can identify the potential targets for a particular miRNA based on the seed sequence it uses to bind to usually the 3′UTR of the target mRNA (Oulas et al., 2015). To determine which targets are relevant to s...
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miR-137, a brain-enriched microRNA, is involved in the control of neuronal proliferation, differentiation, and dendritic arborization, all of which are important for proper neurogenesis and relevant to schizophrenia. miR-137 is also known to regulate many genes implicated in schizophrenia risk. Although reports have associated the miR-137 polymorphism rs1625579 with this disease, their results ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2014
ISSN: 1422-0067
DOI: 10.3390/ijms15023262