MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2
نویسندگان
چکیده
منابع مشابه
miR‐148b inhibits glycolysis in gastric cancer through targeting SLC2A1
Although the molecular biology of GC has been well characterized, early diagnostic biomarkers and effective therapeutic options in gastric cancer are still under investigation. Here, we found that miR-148b expression decreased in human gastric cancer tissues compared with matched adjacent nontumor tissues by q-PCR analysis and in situ hybridization. Further investigation revealed that overexpre...
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متن کاملPKM2 and cancer: The function of PKM2 beyond glycolysis
Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2019
ISSN: 1734-1922,1896-9151
DOI: 10.5114/aoms.2019.87812