Minor structural modifications of bisphenol A strongly affect physiological responses of HepG2 cells
نویسندگان
چکیده
منابع مشابه
Mutagenicity and DNA damage of bisphenol A and its structural analogues in HepG2 cells.
Environmental oestrogen bisphenol A (BPA) and its analogues are widespread in our living environment. Because their production and use are increasing, exposure of humans to bisphenols is becoming a significant issue. We evaluated the mutagenic and genotoxic potential of eight BPA structural analogues (BPF, BPAF, BPZ, BPS, DMBPA, DMBPS, BP-1, and BP-2) using the Ames and comet assay, respectivel...
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Esculetin (6,7-dihydroxycoumarin) and its C-4 derivatives have multiple pharmacologic activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Glucuronidation plays important roles in catechols elimination, although thus far the effects of structural modifications on the metabolic selectivity and the catalytic efficacy of the human...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2019
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-019-02457-y