منابع مشابه
The significant other: splicing by the minor spliceosome
The removal of non-coding sequences, introns, from the mRNA precursors is an essential step in eukaryotic gene expression. U12-type introns are a minor subgroup of introns, distinct from the major or U2-type introns. U12-type introns are present in most eukaryotes but only account for less than 0.5% of all introns in any given genome. They are processed by a specific U12-dependent spliceosome, ...
متن کاملMinor spliceosome components are predominantly localized in the nucleus.
Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major U2-dependent spliceosome, and further that the minor spliceosome functions in the cytoplasm. To study the subcellular localization of the snRNA components of both the major and minor spliceosomes, we performed in situ hybridizations with mouse tissues and human...
متن کاملWhere in the cell is the minor spliceosome?
Joan A. Steitz*†, Gideon Dreyfuss‡, Adrian R. Krainer§, Angus I. Lamond¶, A. Gregory Matera , and Richard A. Padgett** *Yale University and Howard Hughes Medical Institute, New Haven, CT 06536; ‡University of Pennsylvania School of Medicine and Howard Hughes Medical Institute, Philadelphia, PA 19104-6148; §Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724; ¶University of Dundee, Dunde...
متن کاملSplicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation
The functional relevance and the evolution of two parallel mRNA splicing systems in eukaryotes--a major and minor spliceosome that differ in abundance and splicing rate--are poorly understood. We report here that partially spliced pre-mRNAs containing minor-class introns undergo nuclear export and that minor-class snRNAs are predominantly cytoplasmic in vertebrates. Cytoplasmic interference wit...
متن کاملDefective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency
The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused by biallelic mutations in the RNPC3 gene, which codes for a minor spliceosome protein required for U11/U12 small nuclear ribonucleoprotein (snRNP) formation and splicing of U1...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2018
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2017.09.036