Minimal change disease and focal segmental glomerulosclerosis

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منابع مشابه

Minimal change disease and focal segmental glomerulosclerosis.

Minimal change disease (MCD) accounts for greater than 90% of cases of nephrotic syndrome in children. In adults, MCD accounts for 10–15% of nephrotic syndrome. FSGS is increasing in incidence in adults and children, and in the USA, in adults, is now the most common cause of nephrotic syndrome w1,2x. MCD shows normal glomeruli by light microscopy. Associated acute interstitial nephritis suggest...

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Rituximab in adult minimal change disease and focal segmental glomerulosclerosis.

Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing immunosuppressive agents with potential toxic side effects also restricts their long-term use. Rituximab, ...

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Significance of C4d expression in minimal change disease and focal segmental glomerulosclerosis

C4d is a by-product of the lectin complement pathway. Glomerular C4d deposition is related to poor prognosis in various forms of immune-mediated glomerulonephritis. The aim of this study was to elucidate the role of the lectin pathway in minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). C4d immunohistochemical staining was performed on 130 renal biopsy tissue specimens...

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Urinary Peptide Profiling to Differentiate between Minimal Change Disease and Focal Segmental Glomerulosclerosis

BACKGROUND Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are the main causes of primary idiopathic nephrotic syndrome in children and adults, with diagnosis being essential for the appropriate choice of therapy and requiring renal biopsy. However, the presence of only normal glomeruli on renal biopsy of FSGS patients may lead to the misclassification of thes...

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Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis

BACKGROUND Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are glomerular diseases characterized by nephrotic syndrome. Their diagnosis requires a renal biopsy, but it is an invasive procedure with potential complications. In a small biopsy sample, where only normal glomeruli are observed, FSGS cannot be differentiated from MCD. The correct diagnosis is crucia...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 2001

ISSN: 1460-2385,0931-0509

DOI: 10.1093/ndt/16.suppl_6.74