Mingling with Neanderthals

Chromosomal Organization: Mingling with the Neighbors

C hromosomes, the packaged DNA carriers of heredity and instructions for proper cell functioning, undergo dramatic morphological transformations during the cell-division cycle. In metaphase, which includes the alignment of chromosomes before their separation between the two daughter cells, the 46 chromosomes in a human cell are condensed to such a degree that they can be observed by light micro...

Mingling: mixed-integer rounding with bounds

Mixed-integer rounding (MIR) is a simple, yet powerful procedure for generating valid inequalities for mixed-integer programs. When used as cutting planes, MIR inequalities are very effective for mixed-integer programming problems with unbounded integer variables. For problems with bounded integer variables, however, cutting planes based on lifting techniques appear to be more effective. This i...

Virtual Neanderthals

Our closest hominid relatives may have died out 30,000 years before the arrival of the computer, but thanks to modern genomics and scanning technology, they are now very present in the 21st century and can even help us understand our own species.

Morphology, paleoanthropology, and Neanderthals.

Morphology carries the primary signal of events in the evolutionary history of any group of organisms but has been relatively neglected by paleoanthropologists, those who study the history of the human species. Partly this is the result of historical influences, but it is also due to a rather fundamentalist adherence among paleoanthropologists to the tenets of the Neodarwinian Evolutionary Synt...

Cell mingling during mammalian embryogenesis.